Title Overview of Model building strategies in population PK/PD analyses: 2002 to 2004 literature survey
نویسندگان
چکیده
1 Université de Lyon, Lyon, F-69003, France ; université Lyon 1, EA3738, CTO, faculté de médecine Lyon Sud, Oullins, F-69600, France. 2 INSERM U738, Paris, France, AP-HP, Hôpital Bichat, Département d'Epidémiologie, Biostatistique et Recherche Clinique, Paris, France. 3 Institut de Recherches Internationales Servier, Courbevoie, France. 4 EXPRIMO NV, Lumnen, Belgium. 5 Centre anticancéreux Léon Bérard, Lyon, F-69008, France.
منابع مشابه
Article Title Article Title Pattern analysis using fuzzy VIKOR in locating educational facilities district Case Study: District 14 of Tehran Metropolis
With the increasing population in cities, particularly big cities, demand for public goods and services increased too. But, due to certain political-economic structure of the country, often the rates of supplies growth have been less than the demands’. The high-demand applications such as educational, for many reasons including, Lack of cities’ coordination executive bodies, financial problems ...
متن کاملInvestigating the mediating role of attitudes to reading in relation to cognitive strategies, metacognitive reading strategies, parents' attitudes to reading with reading motivation students with reading difficulties
The aim of this study was to investigate the mediating role of attitudes toward reading in relation to cognitive strategies, metacognitive reading strategies, parents' attitudes to reading with reading motivation for students with reading difficulties. The research method was descriptive correlational and in particular structural equation model. For this purpose, the statistical population of t...
متن کاملPharmacokinetic/Pharmacodynamic (PK/PD) Relationship-based Approach to Understand the Variability of Central Neurological Effects of Ethanol
Pharmacokinetic/pharmacodynamic (PK/PD) relationships describe the quantitative relationships between the drug-induced effects and the concurrent corresponding drug concentrations in an individual. Since a long time, rough qualitative relationships have been described between neurological presentation and plasma ethanol concentration in acute ethanol ingestion. However, to date, precise quantit...
متن کاملPopulation PK/PD Analysis
Pharmacokinetics and pharmacodynamics are divisions of pharmacology that study the action of the body on the drug and the action of the drug on the body, respectively. They complete dose titration studies aimed to select rational dosage regimens. The classical pharmacokinetic (PK)/pharmacodynamic (PD) studies are experimental. They are usually performed on healthy volunteers or highly selected ...
متن کاملMonte Carlo simulations: maximizing antibiotic pharmacokinetic data to optimize clinical practice for critically ill patients.
Infections in critically ill patients continue to result in unacceptably high morbidity and mortality. Although few data exist for correlating antibiotic exposure with outcome, antibiotic dosing is likely to be highly important for maximizing resolution of infection in many patients. The practical and financial difficulties of performing pharmacokinetic (PK) studies in critically ill patients m...
متن کامل